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KMID : 0357319950300010013
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Journal of the Korean Society for Microbiology
1995 Volume.30 No. 1 p.13 ~ p.22
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Accelerated Hair Growth at the Injection Sites of Cholera Toxin
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Abstract
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We observed the unexpected but noticeable phenomenon that hair growth was accelerated in clearly marginated, round and localized from at the injection sites of cholera toxin. Cholera toxin had been injected intradermally in the back-skin of
rabbit.
Accelerated hair growth areas appeared noticeably after rabbits were being maintained for 25 days. Hair growth accelerated at all the 14 portions injected with cholera toxin(100%), but was not at all the 3 control portions injected with PBS(()%)
Accelerated hair growth areas were roughly in proportion to induration sizes due to cholera toxin injected intradermally. Hair height and thickness between accelerated hair growth portions and control portions could be differentiated grossly.
Hair
height was 12.4(±)mm at the accelerated hair growth portions and 5.8(±1.3)mm at the control portions. Hair thickness of the accelerated hair growth portions was also more thick than of control portions.
Phenomenon of the localized accelerated hair growth with clear and round margin may be due to increased vasopermeability at the injection sites of cholera toxin. The action mechanism of cholera toxin differs from those of other drugs such as
minoxidil
and cyclosporins with hypertrichotic side effect. Therefore, it is suggested that these results may be used for more detailed understanding of hair growth and as basis for development of a new topical agent for prevention and therapy of alopecia,
such
as minoxidil.
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